The college has pharmacy, pharmaceutical preparation, Chinese medicine, clinical pharmacy 4 undergraduate majors.It has 35 provincial and university-level teaching quality engineering projects in pharmacology, natural pharmaceutical chemistry, pharmacognosy, biochemistry, pharmaceutical management, etc.It has 9 teaching and research offices, 2 laboratories and analysis and testing centers, including teaching laboratories and research laboratories.Hosting experimental Animal Center of Henan University.
The school has two first-level disciplines, namely pharmacy and Traditional Chinese Medicine, and two first-level disciplines, namely pharmacy and Education, as well as professional master's degree programs in medicine and health care.In April 2017, the TCM major passed the professional certification organized by the Teaching Steering Committee for TCM majors of the Ministry of Education.Traditional Chinese medicine and pharmacy are the key first-level disciplines in Henan Province.The research team of medicinal substances and innovative Drugs of Traditional Chinese Medicine and the research and development team of dual-use medicine and food resources are the innovation teams of Colleges and universities in Henan Province.
In 2005, the pharmacy discipline of Henan University was granted the right to confer master's degrees in first-level disciplines, and it carries out teaching and scientific research with the support of the "Drug Laboratory" of Henan University, the Key Laboratory of Natural Medicine and Immunology Engineering of Henan Province and the Experimental Teaching Demonstration Center of Henan Province.
In recent years, the discipline has undertaken 9 projects supported by the National Natural Science Foundation of China, including "Synthesis of anti-tumor fluoroquinolone C-3 heterocyclic carboxylic acid", and 64 projects funded by provincial and other scientific research funds. Since 2009, 8 monographs have been published in the special edition, and 220 academic papers have been published, including 45 SCI papers and 170 Chinese core journals.
(1) The molecular design and synthesis of anti-cancer drug research methodology this direction mainly in: based on the effect of antibacterial fluoroquinolone target topoisomerase (TOPO) and mammalian TOPO has the similarity, the structure and function of the use of the electronic principle, such as using (thick) as heterocyclic carboxylic and other body get high activity, low toxicity characteristics of anti-tumor fluoroquinolone to compound;At the same time, polyamine fluoroquinolones were designed based on the characteristics of the polyamine transport system, which successfully solved the problems of water-solubility and in vivo absorption of anti-tumor fluoroquinolones, and some candidate compounds were expected to enter the pre-clinical evaluation.The high efficient chiral catalyst cyclic polyguanidine was found in the synthesis method, which provided the methodology basis for the design and synthesis of chiral antitumor quinolones.Through the secondary development of the structure and mechanism of the existing drugs, the lead compounds with new uses are found, which is expected to make a new breakthrough in the transformation of fluoroquinolones from antibacterial activity to anti-tumor activity, and to find a new way for the discovery of new structure of anti-tumor drugs.
(2) Research on natural active ingredients and Drug Quality Evaluation This direction will conduct in-depth research on extraction and separation technology, structural modification and quality standards of natural active ingredients.In China, supramolecular technology was first used to study natural drugs, which provided new ideas and methods for the preparation of effective components of natural drugs and the improvement of quality standards.Andrographolide with definite anti-tumor effect was taken as the lead compound to synthesize a series of derivatives, and two andrographolide derivatives were found to have significant anti-tumor activity in vivo for the first time, laying a foundation for the application of innovative anti-tumor drugs in Traditional Chinese medicine.In this discipline, the research project of andrographis paniculata effective site (AEP) for the treatment of lung cancer is expected to develop a new drug for the treatment of lung cancer.
(3) the central degenerative disease and tumor treatment basic research with the aid of this discipline animal in vivo model and a variety of in vitro cell model to simulate the truly diseases such as stroke, alzheimer's disease occurrence and development process, and observe the benzene hai suo, Dorset, sodium alginate double ester drugs such as the prevention and treatment of this kind of disease, for the drug provides the basis for further research and development;Dynamic study on the blood-brain barrier after cerebral ischemia and the change rule of P - glycoprotein function and expression that result in the change of P - glycoprotein function and expression mechanism and corresponding signal pathway, to accurately grasp the drug treatment of cerebral ischemia time, eventually improve the therapeutic effect of cerebral ischemia drugs has provided important experimental basis and specific drug targets.
(4) Microbial and biochemical pharmaceutical research and development of innovative genetic engineering drugs in the direction of drug screening through target, isolation and purification of Chinese herbal medicine and analysis and determination of monomer structure;To study the regulation of drug metabolism mediated by nuclear receptors and its molecular mechanism, and to develop nuclear receptors and molecular pharmacology;Through the observation and analysis of anti-tumor drug treatment of tumor cells and its killing effect on tumor cells, the molecular mechanism of anti-tumor drug action was studied.Through the observation of the cytotoxicity and molecular mechanism of the active components of natural drugs, the molecular basis research of the active components of natural drugs was carried out.Through the establishment of the corresponding molecular, cell, tissue and animal models, and drug screening and evaluation, anti-aging drug pharmacology and pathological mechanism research.
(5) Research and Application of pharmaceutical preparation Technology This direction mainly focuses on the research and application of modern pharmaceutical preparation technology, such as nano pharmaceutical preparation and delayed and controlled release pharmaceutical preparation technology, precursor pharmaceutical and biological pharmaceutical preparation technology.In the process of drug research and development and preparation into drugs, drugs need to be processed through pharmaceutical preparation technology. Therefore, the research and application of modern pharmaceutical preparation technology has deep advantages of production, education, research and application, and has engineering characteristics.
The pharmacy discipline in this direction is the seventh batch of key disciplines in Henan Province, which has great influence in the pharmacy education in Colleges and universities of Henan Province.It is expected that this direction will make a breakthrough in the research and application of modern pharmaceutical preparation technology, such as delayed and controlled release preparation, and play an extremely important role in training academic graduate students and professional degree graduate students, and promoting the development of medical economy in our province.
In 2003, the discipline of Traditional Chinese Medicine of Henan University was granted the right to confer master's degree of first-level discipline, and in 2008, it was approved to be a first-level key discipline of Henan Province.It has the Academician workstation of Henan Province for the study of anti-tumor Traditional Chinese medicine pharmacodynamic substances, the Key Laboratory of Henan Province for Natural Medicine and Immune Engineering, and the Inorganic Ion exchange resin Engineering Center of Henan University.National engineering technology research center of henan branch, henan medicinal material with innovative drug research team, the level 1 discipline of Chinese materia medica professional master's degree award authority, cortex eucommiae cultivation and utilization of engineering technology research center of colleges and universities in henan province, henan province pharmaceutical experimental teaching demonstration center, efficacy material base cultivate laboratory in henan province colleges and universities.
Undertook the national public welfare project "Research on the establishment and Comprehensive Utilization of Eucommia ulmoides breeding Population";Research on key regulatory proteins of hypoxic microenvironment in the occurrence of lung cancer with National Natural Science Foundation of China and study on the relationship between structure and toxicity and mechanism of steroid alkaloids with neurogenotoxic veratrol;Anticancer mechanism of Naphthalimide polyamine conjugate supported by The Chinese Postdoctoral Science Foundation;Study on the relationship between efficacy and toxicity of micellar drug release system under the National Science and Technology Basic Conditions Platform;As well as new drug innovation, horizontal projects and other 78.
He has published 13 works, including the 2010 Edition of Chinese pharmacopoeia: Clinical Medication Instructions, Medicinal Botany, Modern Prescription New Solution, animal Medicine, etc. He has published more than 280 academic papers, including 24 SCI and EI, and 159 Chinese core journals.
(1) the study of traditional Chinese medicine quality control method, using the method such as fingerprint, LC - MS method to study the quality control of traditional Chinese medicine, discovered the main secondary metabolites of the bark of eucommia synthesis genes, and formulated the industry standard of eucommia ulmoides oil, eucommia tea, the major active constituent of eucommia ulmoides was established to extract and quality control system, and clarified the hellebore of steroidal alkaloid poison relations and the mechanism of action.
(2) Pharmacology and toxicology of Traditional Chinese medicine, combining traditional Chinese medicine theory with modern pharmacology, studying the effective components, positions, rational formulations and mechanisms of traditional Chinese medicine at the cellular and molecular levels, and taking the lead in establishing the evaluation system of tumor cell membrane polyamine transporters and the screening platform for the active components of traditional Chinese medicine against HIV;To study the pharmacokinetics of the active ingredients of Traditional Chinese medicine and reveal the scientific connotation of the theory of traditional Chinese medicine.
(3) Research on the active ingredients of Traditional Chinese medicine, using CO2 supercritical extraction, membrane separation and other technologies to extract the active ingredients of traditional Chinese medicine, and the structural modification of the active monomer and the development of new drugs, screening the active ingredients that inhibit -glycosidase, and the development of hypoglycemic drugs.Independent research and development of inorganic ion exchange resin drug separation technology, to solve the world's problem of heavy metals in Traditional Chinese medicine exceed the standard.
(4) Research on traditional Chinese medicine resources and utilization, focusing on the collection and evaluation of traditional Chinese medicine resources such as Eucommia ulmoides, cloning of important genes related to activity and cultivating new varieties;Established the world's largest eucommia ulmoides germplasm bank, conducted standardized planting research, and established GAP base.Dig throat grass, fragrant wood fungus, mung bean cohosh and other folk herbs.
(5) Research on new preparations and pharmacokinetics of Traditional Chinese medicine, and research on new drug delivery systems such as nano new drug delivery systems and polymer micelles under the guidance of theories of traditional Chinese medicine;The research and development of new Chinese medicine drugs has obtained the approval of ginkgo ketone dropping pills, Banlangen lozenges, Shuanghuanglian lozenges, Yujinfan capsules and Qishen capsules, and many other new Chinese medicine drugs with independent intellectual property rights.
